Recently, platelet-rich plasma (PRP) emerges into many medical specialties especially the degenerative disease such as knee joint, eye and reproductive medicine as well. At first, PRP was used to rejuvenate the endometrium lining in case of repeated implantation failure and intrauterine adhesion after surgery (aka Asherman syndrome) with good results.

Then, PRP was injected into ovary of woman who had ovarian failure and found that this simple treatment can increase the follicle number and also the quality of eggs. Finally, the term ‘Ovarian Rejuvenation with PRP’ was coined.

The actual effect of PRP on follicle and egg is still a mystery. Basically, platelet act as a primary mechanism to combat physical injury to the body by forming a biological bandage to the wound and further promote wound healing by releasing many growth factors and cytokines. The secreted factors from platelet might activate the resting pool of ovarian follicle or enhance the differentiation of oogonial stem cell that might still reside within ovary.

First, two tubes of your blood will be collected in special tubes and PRP will be prepared with special centrifugation protocol. About 10 minutes afterward, the PRP will be ready to infuse into ovary by special needle through ultrasound-guided. After about one hour of recovery, you can go home right away. You might only feel a slight discomfort on both side of the pelvis which is temporary and harmless.

After a couple of weeks, ovarian reserve test such as AMH, FSH+E2 and antral follicle number should improve. Higher number of eggs retrieved should be seen in the following cycles. These effects will last for 2-3 months

Since PRP is extracted from your own blood, there is no adverse effect. Only slight discomfort and slight bleeding which should be stopped within a day might be observed.